Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (6) Autor Branco,L.G.S. (6) Carvalho-Costa,P.G. (2) Leite-Panissi,C.R.A. (2) Anselmo-Franci,J.A. (1) Fabris,G. (1) Gargaglioni,L.H. (1) Nascimento,C.G.O. (1) Paula,P.M. de (1) Mais... Palavra-chave Antinociception (2) Carbon monoxide (2) Nitric oxide (2) Ventilation (2) Acute stress (1) Alpha-Methyl-4-carboxyphenyl-glycine (MCPG) Hypoxia Ventilation Body temperature (1) Amphibian (1) Body temperature (1) CGMP (1) CO2 (1) Formalin (1) Heme oxygenase (1) Heme oxygenase Carbon monoxide Locus coeruleus Anxiety Elevated plus maze (1) Hypercapnia (1) Hypernociception (1) Hypoxia (1) Kynurenic acid --> (1) L-NAME (1) Lateral cerebral ventricle (1) Light/dark box (1) Mais... Tipo do documento Info:eu-repo/semantics/article (6) Ano 2016 (1) 2014 (1) 2009 (1) 2004 (1) 1999 (2) País Brazil (6) Idioma Inglês (6)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 6 Primeira ... 1 ... Última Activation of locus coeruleus heme oxygenase-carbon monoxide pathway promoted an anxiolytic-like effect in rats BJMBR Carvalho-Costa,P.G.; Branco,L.G.S.; Leite-Panissi,C.R.A.. The heme oxygenase-carbon monoxide pathway has been shown to play an important role in many physiological processes and is capable of altering nociception modulation in the nervous system by stimulating soluble guanylate cyclase (sGC). In the central nervous system, the locus coeruleus (LC) is known to be a region that expresses the heme oxygenase enzyme (HO), which catalyzes the metabolism of heme to carbon monoxide (CO). Additionally, several lines of evidence have suggested that the LC can be involved in the modulation of emotional states such as fear and anxiety. The purpose of this investigation was to evaluate the activation of the heme oxygenase-carbon monoxide pathway in the LC in the modulation of anxiety by using the elevated plus maze test (EPM)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heme oxygenase Carbon monoxide Locus coeruleus Anxiety Elevated plus maze; Light/dark box. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000500601 Acute stress-induced antinociception is cGMP-dependent but heme oxygenase-independent BJMBR Carvalho-Costa,P.G.; Branco,L.G.S.; Leite-Panissi,C.R.A.. Endogenous carbon monoxide (CO), which is produced by the enzyme heme oxygenase (HO), participates as a neuromodulator in physiological processes such as thermoregulation and nociception by stimulating the formation of 3′,5′-cyclic guanosine monophosphate (cGMP). In particular, the acute physical restraint-induced fever of rats can be blocked by inhibiting the enzyme HO. A previous study reported that the HO-CO-cGMP pathway plays a key phasic antinociceptive role in modulating noninflammatory acute pain. Thus, this study evaluated the involvement of the HO-CO-cGMP pathway in antinociception induced by acute stress in male Wistar rats (250-300 g; n=8/group) using the analgesia index (AI) in the tail flick test. The results showed that antinociception... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heme oxygenase; Carbon monoxide; CGMP; Lateral cerebral ventricle; Acute stress; Antinociception. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201057 Antinociception synergy between the peripheral and spinal sites of the heme oxygenase-carbon monoxide pathway BJMBR Nascimento,C.G.O.; Branco,L.G.S.. We have shown that the peripheral and spinal cord heme oxygenase (HO)-carbon monoxide (CO)-soluble guanylate cyclase-cGMP pathways play an important role in antinociception in the rat experimental formalin model. Our objective was to determine if there is synergism between peripheral (paw) and spinal HO-CO pathways in nociception. Rats were handled and adapted to the experimental environment for a few days before the formalin test, in which 50 µL of a 1% formalin was injected subcutaneously into the dorsal surface of the right hind paw. The animals were then observed for 1 h and the frequency of flinching behavior was taken to represent the nociceptive response. Thirty minutes before the test, rats were pretreated with intrathecal injections of the HO... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nociception; Carbon monoxide; Formalin; Hypernociception; Antinociception. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100020 Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia BJMBR Paula,P.M. de; Branco,L.G.S.. The interaction between pulmonary ventilation (V E) and body temperature (Tb) is essential for O2 delivery to match metabolic rate under varying states of metabolic demand. Hypoxia causes hyperventilation and anapyrexia (a regulated drop in Tb), but the neurotransmitters responsible for this interaction are not well known. Since L-glutamate is released centrally in response to peripheral chemoreceptor stimulation and glutamatergic receptors are spread in the central nervous system we tested the hypothesis that central L-glutamate mediates the ventilatory and thermal responses to hypoxia. We measured V E and Tb in 40 adult male Wistar rats (270 to 300 g) before and after intracerebroventricular injection of kynurenic acid (KYN, an ionotropic glutamatergic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Kynurenic acid -->; Alpha-Methyl-4-carboxyphenyl-glycine (MCPG) Hypoxia Ventilation Body temperature. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000019 Participation of nitric oxide in the nucleus isthmi in CO2-drive to breathing in toads BJMBR Gargaglioni,L.H.; Branco,L.G.S.. The nucleus isthmi (NI) is a mesencephalic structure of the amphibian brain. It has been reported that NI plays an important role in integration of CO2 chemoreceptor information and glutamate is probably involved in this function. However, very little is known about the mechanisms involved. Recently, it has been shown that nitric oxide synthase (NOS) is expressed in the brain of the frog. Thus the gas nitric oxide (NO) may be involved in different functions in the brain of amphibians and may act as a neurotransmitter or neuromodulator. We tested the hypothesis that NO plays a role in CO2-drive to breathing, specifically in the NI comparing pulmonary ventilation, breathing frequency and tidal volume, after microinjecting 100 nmol/0.5 µl of L-NAME (a... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Amphibian; Hypercapnia; Ventilation; Nucleus isthmi; Toad; CO2; L-NAME. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100010 Role of nitric oxide in hypoxia-induced hyperventilation and hypothermia: participation of the locus coeruleus BJMBR Fabris,G.; Anselmo-Franci,J.A.; Branco,L.G.S.. Hypoxia elicits hyperventilation and hypothermia, but the mechanisms involved are not well understood. The nitric oxide (NO) pathway is involved in hypoxia-induced hypothermia and hyperventilation, and works as a neuromodulator in the central nervous system, including the locus coeruleus (LC), which is a noradrenergic nucleus in the pons. The LC plays a role in a number of stress-induced responses, but its participation in the control of breathing and thermoregulation is unclear. Thus, in the present study, we tested the hypothesis that LC plays a role in the hypoxia-induced hypothermia and hyperventilation, and that NO is involved in these responses. Electrolytic lesions were performed bilaterally within the LC in awake unrestrained adult male Wistar rats... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Locus coeruleus; Hypoxia; Ventilation; Body temperature; Rat. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100009 Registros recuperados: 6 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco